The International Society for Research on Trisomy 21 : 2015 Conference


1st meeting of the Trisomy 21 Research Society

Changing Paradigms in Down Syndrome

Sponsored by
The Global Down Syndrome Foundation
The Fondation Jerome Lejeune
F. Hoffman- LaRoche, Ltd
The Lumind Foundation
Trisomie 21 France
The Matthews Foundation
Linda Crnic Institute

The International Society for Research on Trisomy 21 (T21RS) is the first non-profit organization of researchers working on trisomy 21 (Down's syndrome). It was founded to promote basic and clinical research on trisomy 21 and to allow the use of new knowledge for the development of treatments.

If you happen to find this website and are interested in T21RS (Trisomy 21 Research Society), you can find more information about this scientific organization of researchers studying Down syndrome at:

It aims are to:

  • stimulate research trisomy 21;
  • facilitate interactions and collaborations between researchers
  • organize biannual conference T21RS;
  • co-ordinate clinical research protocols and pre-clinical;
  • garner  financial support for training of young researchers;
  • explain recent discoveries to the public and policy makers;
  • promote interactions between researchers, patient associations and families of patients and pharmaceutical companies.


Conference Dates: June 4-7,  2015 



Dear Colleague,

For years the rather small international community of researchers committed to understand the effects of trisomy 21 and to use this knowledge to expand opportunities for people with Down syndrome has struggled to obtain resources to support research, to recruit new generations of investigators to this area, and to enable investigators to communicate with each other to reach common goals.

A core group of those investigators have established the Trisomy 21 Research Society, an international professional organization for those engaged in Down syndrome research. The Society will provide a nexus for organizing communication between researchers and with organizations that have the means to disseminate this news to families; to assure that young researchers see the excitement and potential of a career in a rapidly advancing area of research that is making contributions to the quality of life for people with Down syndrome every day; and to coordinate a biannual international meeting of investigators.

This first meeting will be held in Paris in the Hospital Pitié Salpetrière famous in history of neurosciences in the Brain and Spine Institute's new building.

This three and half day event will discuss many aspects of Down syndrome from development to aging and clinical trials in an informal academic setting. Topics for discussion include molecular mechanisms, animal modelling, drug discovery and care.  With plenty of opportunity for networking and debating, this informal international meeting will bring you up to date with current research and thinking regarding Down syndrome.

Doctor Jean Delabar, President of T21RS




The scientific sessions will be held from 8 am to 17h from June 4 to 6 On June 7, the T21RS General Meeting will be held from 8:30 to 10 am and a session with parents' associations and foundations will take place between 10.30 and 13.00.


The meeting will be held at the Institute for Brain and Spinal Cord Disorders (ICM) in the heart of the Pitié-Salpêtrière


Registration fees cover the scientific sessions, a book of notes, cocktail, lunch on Thursday, Friday and Saturday and the conference banquet on Friday.


Members: 300 €

Academic or Parent: € 400

Corporate Presence: 600 €


A limited amount of funding available to finance the costs of travel or hotel accommodations. Support is subject to the acceptance of a dossier submitted to the commission and the availability of funds. For further information contact R Bartesaghi or JM Delabar.





President: Jorge Busciglio, PhD, of neurobiology and behavior, UCI, Irvine; MC Potter, PhD, ICM, Paris; E Head, PhD, Sanders-Brown Center on Aging, Kentucky; F Wiseman, PhD, University College London; K Gardiner, Ph.D., Department of Pediatrics, University of Colorado, Denver; M Dierssen, MD, Ph.D., Center for Biomedical Research on rare diseases-CIBERER, Barcelona; J O'Bryan, PhD, Department of Pharmacology, University of Illinois, Chicago; R Bartesaghi, PhD, Department of Biomedical Sciences and neuromotor, University of Bologna.


MC Potter, PhD, ICM, Paris; Jean Delabar, Ph.D., University of Paris Diderot and ICM, Paris; Bernadette Allinquant, Psychiatry and Neuroscience Center; Nathalie Janel, Ph.D., University of Paris Diderot, Paris confirmed speakers MC Potter, N Janel, JM Delabar, Duyckaerts C, J Busciglio, R Reeves, M Dierssen.

This website was created to promote the 2015 Trisomy 21 Research Society's conference.

Since I have a cousin with Down's Syndrome, when I discovered that's domain was available, I decided to buy it with the goal of recreating some of its content from archived pages. I definitely didn't want someone else purchasing the domain and re-purposing the site for something that had nothing in common with the Trisomy 21 Research Society, and Down syndrome research. I enjoy building websites. My latest job has been working for an e-commerce site that has the best selection of wholesale vapor products. I work with their webmaster to make the site more user friendly for their vaping customers, as well as work on the SEO aspects to help the site rank better with its organic search results. I have learned a lot about vaping products and read numerous articles regarding the pros and cons of vaping. Since it is an exploding marketplace the verdict especially regarding whether e-cigarettes should be regulated, and how strictly, is being debated by regulatory agencies around the world. Several medical organizations have called for restrictions on use of the increasingly popular vaping devices. Although long-term risks of e-cigarettes remain unknown, the new study concluded the benefits of e-cigarettes as a no-smoking aid appear at this point to outweigh potential harms.

The goals of the Trisomy 21 Research Society (T21RS) is worthy. More people should learn about them.



More Background On The International Society for Research on Trisomy 21 : 2015 Conference

The Trisomy 21 Research Society (T21RS) is a pioneering international non-profit scientific organization dedicated to fostering research on Down syndrome, also known as Trisomy 21. Established in 2014 under Dutch law, T21RS boasts membership from over 275 researchers across 28 countries, making it the first of its kind in this field of study. The society's foundational goals include stimulating Down syndrome research, facilitating collaboration among scientists, organizing biennial international conferences, harmonizing research protocols, supporting the education and training of young researchers, and effectively disseminating research findings to the general public and policy makers.

T21RS has successfully organized several international conferences that serve as key platforms for the exchange of scientific knowledge and advancements in Down syndrome research. The inaugural conference took place in Paris in June 2015, emphasizing the theme "Changing paradigms in Down syndrome" and drawing scientists, clinicians, and various association members. Subsequent conferences continued to build on this momentum, with the second conference in Chicago in June 2017 themed "Paving the way for therapy," and the third in Barcelona in June 2019, focusing on "Science for future Therapy." These conferences have been instrumental in promoting scientific exchange, maximizing resource use, and defining the most promising research at basic, translational, and clinical levels​.

The fourth international conference, held in Long Beach, California, from June 9-12, 2022, marked a return to face-to-face meetings after the COVID-19 pandemic. It attracted 265 international researchers, physicians, and industry representatives who engaged in discussions and presentations on Down syndrome research. The conference featured keynote presentations, scientific symposia, mini-symposia, satellite sessions, and a session on science and its implication in society. Highlighting the importance of young scientists in the field, several were sponsored to attend, contributing to the ongoing development of research and clinical practices aimed at improving the lives of people with Down’s syndrome.

Notably, T21RS also focuses on the broader impact of its work, actively engaging in the GO-DS21 project funded by the European Union’s Horizon 2020 research and innovation programme. This involvement underscores the society's commitment to dissemination, communication, exploitation, and guideline development, aiming to reach a wide range of stakeholders including policy makers and family associations​.

T21RS’s commitment to fostering a collaborative research environment, disseminating knowledge, and advocating for the Down syndrome community showcases its pivotal role in advancing the understanding and treatment of Down syndrome, thereby improving the quality of life for those affected by this genetic condition.


Press & Media Coverage

The Trisomy 21 Research Society (T21RS) International Conferences have garnered significant attention within the scientific and medical communities, reflecting their importance in promoting advances in Down syndrome research. The third T21RS International Conference, which took place in Barcelona in 2019, was highlighted for bringing together 429 scientists, families, and industry representatives. This event focused on sharing the latest discoveries on the cellular and molecular mechanisms of Trisomy 21, cognitive and behavioral challenges, and comorbidities associated with Down syndrome, including Alzheimer’s disease and leukemia. The conference presented an array of cutting-edge results across neuroscience, neurology, psychology, cancer, and pharmacological approaches, emphasizing the global scientific community's commitment to understanding and improving conditions associated with Trisomy 21​.

Furthermore, the T21RS meetings are recognized for their role in facilitating scientific exchange, maximizing resource use, and defining promising research at basic, translational, and clinical levels. The biennial conferences have consistently attracted scientists, clinicians, association members, and foundations, driven by themes like "Changing paradigms in Down syndrome," "Paving the way for therapy," and "Science for future Therapy." These gatherings have been instrumental in establishing a platform for the presentation of innovative research and fostering collaborations within the Down syndrome research community​.

Additionally, organizations such as the Global Down Syndrome Foundation have also recognized and supported the T21RS conferences. For example, the Foundation mentioned its participation in the T21RS conference in Barcelona, Spain, in 2019, highlighting its advocacy workshop for families. This indicates the conferences' reach and impact, extending beyond academic circles to include patient advocacy and support groups, thus bridging the gap between research advancements and community engagement​.

The T21RS International Conferences exemplify the collaborative effort and dedication of the global research community towards advancing understanding, treatment, and care for individuals with Down syndrome, further underlined by the support from various stakeholders, including research institutions, foundations, and families affected by Down syndrome.



The audience for the Trisomy 21 Research Society (T21RS) International Conferences is notably diverse and multidisciplinary, reflecting the wide-ranging interests and specialties within Down syndrome research and care. The conferences have successfully brought together a rich tapestry of participants, including:

  1. Scientists and Researchers: A significant portion of the audience comprises researchers from various fields such as genetics, neuroscience, and cellular biology. These participants are primarily interested in the latest scientific advancements, research methodologies, and findings related to Down syndrome.

  2. Clinicians and Medical Professionals: The conferences also attract a wide range of medical professionals, including doctors, nurses, and therapists who are directly involved in the care of individuals with Down syndrome. They are interested in translating research findings into practical care strategies and improving health outcomes​.

  3. Industry Representatives: Representatives from pharmaceutical companies, biotech firms, and other industries relevant to medical research and healthcare solutions for Down syndrome are also part of the audience. They focus on potential collaborations for developing therapies and drugs.

  4. Families and Caregivers: A unique aspect of the T21RS conferences is the inclusion of families and caregivers of individuals with Down syndrome. These attendees are keen on understanding the latest research that might impact the care, treatment, and quality of life of their loved ones​.

  5. Patient Advocacy and Support Groups: The conferences draw participation from various Down syndrome associations, advocacy groups, and nonprofits. These organizations are focused on advocacy, education, and leveraging research insights to support their communities.

  6. Young Investigators and Students: The T21RS conferences provide a platform for young investigators, graduate students, and postdoctoral researchers to present their work, network with established researchers, and explore career opportunities within Down syndrome research. This audience segment is crucial for the future of Down syndrome research and advocacy​.

The T21RS International Conferences have established themselves as vital events for fostering collaboration, sharing knowledge, and bridging the gap between research, clinical practice, and community support, making them a pivotal gathering for anyone involved in the Down syndrome community.


Known For

The Trisomy 21 Research Society (T21RS) is renowned for several key contributions and initiatives in the field of Down syndrome research and advocacy:

  1. Promoting Down Syndrome Research: T21RS is the first international non-profit scientific organization dedicated to stimulating basic and applied research on Down syndrome. It plays a crucial role in advancing scientific understanding of the genetic, cellular, and physiological aspects of Down syndrome, aiming to improve the quality of life for individuals affected by this condition​.

  2. International Conferences: T21RS is known for organizing biennial international conferences that bring together researchers, clinicians, families, and industry representatives from around the globe. These conferences serve as a platform for presenting the latest research findings, fostering collaborations, and discussing future directions in Down syndrome research. The conferences cover a wide range of topics, including molecular mechanisms, clinical trials, and therapeutic interventions​.

  3. Facilitating Collaboration and Networking: Through its conferences and other initiatives, T21RS fosters collaboration and networking among scientists, medical professionals, and advocacy groups. This collaborative environment is essential for sharing knowledge, resources, and best practices, which accelerates progress in research and improves care for individuals with Down syndrome​.

  4. Support for Young Researchers: T21RS places a strong emphasis on supporting the next generation of researchers in the field of Down syndrome. The society provides opportunities for young investigators to present their work, engage with leading experts, and receive mentorship, thereby nurturing their development and encouraging their ongoing commitment to Down syndrome research​.

  5. Advocacy and Public Engagement: T21RS actively engages in advocacy efforts and public engagement to raise awareness about Down syndrome and the importance of research. The society works to communicate scientific findings to the public, policy makers, and other stakeholders, advocating for the needs and rights of individuals with Down syndrome and their families.

Overall, T21RS is recognized for its leadership in promoting Down syndrome research, its commitment to fostering a collaborative scientific community, and its dedication to improving the lives of individuals with Down syndrome through science and advocacy.



The Trisomy 21 Research Society (T21RS) is an international organization, with its presence and activities extending globally due to its membership base and the scope of its conferences. The society itself is established under Dutch law, indicating its administrative or legal location in the Netherlands. However, its influence and activities span across the world through its conferences, collaborations, and membership from researchers, clinicians, and advocates from numerous countries.

The international conferences organized by T21RS have been held in various locations to reflect its global reach. For instance, the first conference was held in Paris, France, in June 2015. Subsequent conferences took place in different locations, including Chicago, USA, in 2017; Barcelona, Spain, in 2019; and the fourth conference in Long Beach, California, USA, in 2022. The society has announced plans for its fifth conference in Rome, Italy, in June 2024​.

These conferences are instrumental in promoting scientific exchanges and advancements in Down syndrome research at both basic and clinical levels. By rotating the locations of its conferences, T21RS ensures greater accessibility and involvement from the international research community, families affected by Down syndrome, and other stakeholders.



The Trisomy 21 Research Society (T21RS) was founded in 2014 as the first international non-profit scientific organization dedicated to research on Down syndrome, known scientifically as Trisomy 21. It was established under Dutch law and has been recognized as a Public Benefit Organization by the Dutch Tax Administration. The society's formation marked a significant milestone in consolidating global efforts to advance both basic and applied research on Down syndrome, aiming to improve the lives of individuals with this condition​.

T21RS's mission encompasses several key objectives: promoting research on Trisomy 21, facilitating collaborations among researchers worldwide, organizing international conferences biennially, harmonizing research protocols across preclinical and clinical studies, supporting education and training for young researchers, and disseminating research findings to both the scientific community and the public. Moreover, T21RS seeks to foster interactions between researchers, individuals with Down syndrome, their families, and pharmaceutical companies.

The society's biennial international conferences have been a cornerstone of its activities, providing a platform for scientists, clinicians, and other stakeholders to share the latest research findings, discuss challenges and opportunities, and forge collaborations. These conferences have been held in various locations around the world, including Paris, Chicago, Barcelona, Long Beach (California), and an upcoming conference scheduled for Rome. Each conference has focused on a specific theme, reflecting the evolving landscape of Down syndrome research and the priorities of the research community​.

T21RS's history is a testament to the growing recognition of the importance of dedicated research efforts to understand and address the complexities of Down syndrome. Through its initiatives, T21RS has played a pivotal role in bringing together diverse perspectives and expertise to advance the scientific and clinical understanding of Down syndrome, with the ultimate goal of enhancing the quality of life for those affected by it.


Cultural & Social Significance

The cultural and social significance of the Trisomy 21 Research Society (T21RS) and its activities, particularly its international conferences, extends far beyond the realm of scientific research. T21RS plays a crucial role in several broader aspects:

1. Awareness and Understanding

T21RS significantly contributes to increasing public awareness and understanding of Down syndrome. Through disseminating research findings and engaging with the public, the society helps to demystify Down syndrome, educating people about the genetic condition's complexities and the individuals it affects. This increased awareness fosters a more inclusive society where misconceptions about Down syndrome can be challenged and corrected.

2. Community Building and Empowerment

By involving families and individuals with Down syndrome in their conferences and activities, T21RS promotes a sense of community and empowerment. It provides a platform for these individuals and their families to share their experiences, learn about the latest research and therapeutic advances, and connect with others in similar situations. This community-building aspect is crucial for providing emotional support and advocating for the rights and needs of people with Down syndrome.

3. Advancing Healthcare and Therapies

The research fostered by T21RS has direct implications for advancing healthcare and developing new therapies for individuals with Down syndrome. By focusing on understanding the genetic, cellular, and physiological aspects of Down syndrome, T21RS contributes to the development of interventions that can improve health outcomes and quality of life for individuals with Down syndrome. This not only has a significant impact on the affected individuals and their families but also on healthcare systems and policies.

4. Influencing Policies and Advocacy

The work of T21RS, especially through its dissemination of research findings to policymakers and stakeholders, plays a vital role in influencing policies related to Down syndrome. By providing evidence-based information, T21RS aids in the development of policies and programs that support the health, education, and inclusion of individuals with Down syndrome in society. Furthermore, it strengthens advocacy efforts for the rights and well-being of individuals with Down syndrome, promoting social justice and equity.

5. Education and Training

T21RS's commitment to supporting the education and training of young researchers in the field of Down syndrome research ensures the continuation of progress in this field. This focus on education not only advances scientific understanding but also ensures that future generations of researchers and clinicians are prepared to continue the work of improving the lives of individuals with Down syndrome.

Through its multifaceted approach combining research, community engagement, education, and advocacy, T21RS plays a pivotal role in shaping a society that values, supports, and includes individuals with Down syndrome. The society's efforts contribute to a broader cultural and social movement towards inclusivity, respect, and equity for all individuals, regardless of their genetic conditions.